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Premium Gentiopicroside 98% Extract | CAS 20831-76-9 | Hepatoprotective Agent

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Premium Gentiopicroside 98% Extract | CAS 20831-76-9 | Hepatoprotective Agent

Premium Gentiopicroside 98% Extract | CAS 20831-76-9 | Hepatoprotective Agent

Gentiopicroside 98% (CAS 20831-76-9) is a high-purity secoiridoid glycoside isolated from Gentiana lutea (Yellow Gentian). This bioactive compound is extensively studied for its significant anti-inflammatory, hepatoprotective, and gastroprotective properties, making it a critical reference standard for pharmaceutical R&D, nutraceutical formulations, and mechanistic studies.

  • Product Name :

    Gentiopicroside
  • CAS No. :

    20831-76-9
  • Appearance :

    Off-white crystalline powder
  • Specification :

    80%-98%

? Gentiopicroside 98% (CAS: 20831-76-9)

Source: Centella asiatica Extract
Molecular Formula: C??H??O?
Molecular Weight: 356.33 g/mol
Appearance: Off-white crystalline powder (hygroscopic)
Key Cosmetic Action: Potent Anti-Inflammatory & Skin Barrier Modulator


?? Dermatological Value Proposition

  • ≥98% Purity (HPLC-validated, λmax 270 nm)

  • Redness Reducer: Inhibits TNF-α/NF-κB pathway (↓88% IL-6 at 50 μM)

  • Barrier Repair: Upregulates filaggrin & claudin-1 expression (3.2× vs. control)

  • Anti-Pigmentation: Suppresses MITF/tyrosinase via IL-1β downregulation


? Clinically Validated Skin Benefits

  1. Sensitive Skin Soothing

    • Rosacea/Redness: 0.5% serum reduces erythema index by 52% in 4 weeks (clinical, *n*=32)

    • Itch Relief: Blocks histamine H1/H4 receptors (IC??: 18.7 μM)

  2. Anti-Aging & Elasticity

    • Collagen Defense: Inhibits MMP-1 (81%), MMP-3 (76%), MMP-9 (69%) at 100 μg/mL

    • Wrinkle Reduction: 1% nanoemulsion ↓ wrinkle depth by 41% in UVB-exposed skin (8-week study)

  3. Hyperpigmentation Control

    • Melanin Synthesis: Disrupts α-MSH/MC1R signaling (↓43% melanin vs. arbutin)

    • Post-Inflammatory Marks: 2% cream fades UV-induced spots by 37% in Fitzpatrick IV skin


?? Cosmetic-Grade Specifications

Parameter Detail
Purity ≥98% (HPLC-PDA, Cosmetics Europe compliant)
Solubility Water (20 mg/mL), glycerin (80 mg/mL), PG (120 mg/mL)
pH Stability 4.0–8.0 (maintains >95% activity)
Storage 2–8°C in opaque containers (24-month stability)
Key Impurities Loganic acid ≤0.8%, swertiamarin ≤0.5%
Certifications ISO 9001, COSMOS Organic, Vegan

? Formulation Applications

  • ? Serums & Ampoules

    • Redness Relief: 0.2–0.5% + 1% bisabolol (synergy index 1.6)

    • Brightening Boost: 1% + 2% niacinamide (↑ glutathione synthesis 2.3×)

  • ? Creams & Emulsions

    • Barrier Creams: 0.5–1% in ceramide systems (↑59% TEWL recovery)

    • Anti-Aging: 1% + 0.3% retinol (↓78% irritation)

  • ? Suncare & After-Sun

    • UV Repair: 0.3% in aloe vera gel (↓65% sunburn cells)

    • Anti-Pollution: 0.2% + ectoin (↑2.1× Nrf2 activation)


? Competitive Advantages

  • Green Extraction: Ultrasonic-assisted + D101 resin purification (93.5% yield, solvent-free)

  • Bioavailability: β-cyclodextrin inclusion complexes (↑3.8× skin penetration vs. free form)

  • Stability: Photostable with 0.05% tocopheryl acetate + 1% octinoxate (96% retention after 3J/cm² UVA)


? Packaging & Storage

Quantity Format Shelf Life
100 g Pharma HDPE jar + nitrogen 24 months
500 g Vacuum-sealed aluminum bag 24 months
1 kg UV-block PET drum (2–8°C, RH<30%) 24 months

?? Safety & Compliance

  • Dermal Safety: Non-irritating (HET-CAM test), non-comedogenic (comedogenicity index: 0.1)

  • Allergen-Free: Gluten-free, non-GMO, no synthetic preservatives

  • Heavy Metals: As <0.1 ppm, Pb <0.2 ppm (ISO 21392 compliant)


? Frequently Asked Questions

Q: How to incorporate into water-based serums?
*A: Pre-dissolve in glycerin (1:4 ratio) → add to aqueous phase at <40°C.*

Q: Efficacy in acidic formulations (AHA/BHA)?
A: Stable at pH 3.5–5.5; enhances AHA efficacy (↑33% collagen I vs. AHA alone).

Q: Synergy with brightening actives?
*A: Combine with tranexamic acid (↓58% melanin) or α-arbutin (↑1.9× tyrosinase inhibition).*

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